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News & AlertsHighlights Issue 016

Highlights Issue 016

Nipah virus outbreak in Kerala, India. 

The Lancet Infectious Diseases, Volume 25, Issue 10, e548.

Published: October 2025.

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00560-2/abstract?dgcid=raven_jbs_etoc_email


Measles outbreaks in Kyrgyzstan. 

The Lancet Infectious Diseases, Volume 25, Issue 10, e550.

Published: October 2025.

https://www.thelancet.com/action/showCitFormats?doi=10.1016%2FS1473-3099%2825%2900559-6&pii=S1473-3099%2825%2900559-6


China reports chikungunya outbreak. 

The Lancet Infectious Diseases, Volume 25, Issue 10, e551

Published: October 2025.

https://www.thelancet.com/action/showCitFormats?doi=10.1016%2FS1473-3099%2825%2900558-4&pii=S1473-3099%2825%2900558-4


MEDPAGE TODAY: HPV Shot May Protect Unvaccinated Women Too.

From 2006 to 2023, the adjusted proportion of vaccinated women in the U.S. who were positive for the high-risk HPV-16 and HPV-18 types dropped 98.4%.

The proportion of unvaccinated adolescent girls and young women who were positive for at least one of those HPV types dropped 71.6%.

However, social trends and disruptive policies could lead to a drop in HPV vaccination rates.

Published: September 29, 2025.

https://www.medpagetoday.com/pediatrics/vaccines/117706?xid=nl_mpt_DHE_2025-09-29&mh=78b9d767668ebce981a6966b422f64c4&zdee=gAAAAABm4ueYkZNJlwY53sI1rG6_jN7FF2M3EgH5lRHuJb_i8iGzNJ1mRKgUOMs1nOzVDpd2wgb-woUDLozoQ4y0Z5pYMm_74peOnIDehyX-K-eODyiUPmc%3D&utm_source=Sailthru&utm_medium=email&utm_campaign=Daily%20Headlines%20Evening%20-%20Randomized%202025-09-29&utm_term=NL_Daily_DHE_dual-gmail-definition.


Valneva Reports 95% Seroresponse Four Years After Single Shot of Chikungunya Vaccine IXCHIQ®. 

Among the 254 healthy adults still followed in the trial, 95% maintained neutralizing antibody titers well above the seroresponse threshold4 four years after the single-dose vaccination. Persistence of antibodies in older adults (age 65+) was comparable to younger adults (18-64 years of age) in terms of geometric mean titers (GMTs) and seroresponse rates (SRRs).

Published: September 30, 2025.

https://www.biospace.com/press-releases/valneva-reports-95-seroresponse-four-years-after-single-shot-of-chikungunya-vaccine-ixchiq#:~:text=Long%2Dlasting%20antibody%20persistence%20was,and%20seroresponse%20rates%20%28SRRs%29


Has Chikungunya Become Endemic in Southern France. 

In mid-September 2025, the French Health Ministry reported 97 new locally acquired cases of Chikungunya in thirty-eight active clusters. The largest cluster is located in Antibes and consists of 87 cases. This area of France’s Mediterranean coast is a popular vacation destination, located between Cannes and Nice.

Published: September 22, 2025.

https://www.vax-before-travel.com/2025/09/22/has-chikungunya-become-endemic-southern-france


WHO: Highlights from the Meeting of the Strategic Advisory Group of Experts (SAGE) on Immunization 22-25 September 2025. Included topics sere COVID-19, new vaccines for TB, combination vaccines, polio, malaria and AH5 influenza vaccines.

Published: September 2025, however, final publication until December 5, 2025.

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://cdn.who.int/media/docs/default-source/2021-dha-docs/highlights-final-1.pdf?sfvrsn=663ed653_1


WHO: Cholera upsurge (20021 – present). 

Sixty countries reported cases in 2024, an increase from 45 in 2023. The burden of the disease remained concentrated in Africa, the Middle East, and Asia, which collectively accounted for 98% of all reported cases. These trends continue int 2025. This increase in outbreaks and cases is stretching the global capacity to respond. There is a shortage of cholera tools, including vaccines. WHO considers the current global risk from cholera as very high and is responding with urgency to reduce deaths and contain outbreaks in countries around the world.

Published: September 25, 2025.

https://www.who.int/emergencies/situations/cholera-upsurge


Paraguay measles outbreak: Citizens are urged to stay up-to-date on their vaccinations. 

To date, the number of confirmed cases of measles in the country amounts to 45: 43 from San Pedro distributed in Tacuatí (21), Nueva Germania (14) and Santa Rosa del Aguaray (8); and 2 from Central.

Published: October 3, 2025.

https://outbreaknewstoday.substack.com/p/paraguay-measles-outbreak-citizens


Gavi: Why vaccines matter for children. 

10 facts about vaccines, child survival and global progress.

Published: September 22, 2025.

https://www.gavi.org/vaccineswork/why-vaccines-matter-children#:~:text=Over%20the%20past%2050%20years,nearly%2094%20million%20lives%20saved


CEPI backs new research into vaccines against multiple deadly filoviruses.

Supported by up to $18 million in CEPI funding, researchers will design and test innovative vaccine constructs that could offer broad, all-in-one protection against viruses such as Zaire ebolavirus, Marburg virus, Sudan ebolavirus, and even yet-unknown filoviruses that may spill over from animals to humans in the future.

Using advanced artificial intelligence, the team will design immunogens—the components that trigger immune protection—capable of targeting multiple filoviruses. These will be combined with a ferritin-based protein nanoparticle platform to generate a range of vaccine candidates, which will undergo preclinical testing to establish proof of concept. The most promising candidate will be developed to a stage ready for rapid entry into Phase I clinical trials in the event of an emerging outbreak. The ferritin nanoparticle platform is well-suited for low- and middle-income countries, as it does not require complex frozen storage. It has already shown positive safety results in Phase I trials for influenza and COVID-19 vaccines.

Published: October 5, 2025.

https://cepi.net/cepi-backs-new-research-vaccines-against-multiple-deadly-filoviruses


Infection Cotrol Today: Measles in October 2025: 

Why Outbreaks Are Surging—And What Is Changing Now. As of October 1, 2025, the US reported 1,544 confirmed cases across 41 states, the highest national tally in more than three decades; 86%of cases are linked to recognized outbreaks, underscoring sustained transmission in undervaccinated communities.

Published: October 7, 2025.

https://www.infectioncontroltoday.com/view/measles-october-2025-why-outbreaks-are-surging-what-is-changing-now


WHO: Chikungunya virus disease – Global situation. 

In 2025, a resurgence of chikungunya virus (CHIKV) disease was noted in a number of countries, including some that had not reported substantial case numbers in recent years. Between 1 January and 30 September 2025, a total of 445 271 suspected and confirmed CHIKV disease cases and 155 deaths were reported globally from 40 countries, including autochthonous and travel imported cases.

Published: October 3, 2025.

https://www.who.int/emergencies/disease-outbreak-news/item/2025-DON581


Mwamba D, Mboussou F, Akilimali P, Ngandu C, Impouma B, Ihekwazu C, Kamba SR, Janabi MY. New Ebola virus disease outbreak in the Democratic Republic of the Congo: early response guidance. Lancet. 2025 Oct 3:S0140-6736(25)01950-6.

doi: 10.1016/S0140-6736(25)01950-6. Epub ahead of print. PMID: 41052511


Bangladesh launches typhoid vaccination drive to combat drug-resistant threat. 

Bangladesh launched a nationwide vaccination campaign on Sunday to protect millions of children from typhoid, a deadly and increasingly drug-resistant disease that poses a growing public health threat. The month-long campaign aims to immunize around 50 million children aged between nine months and 15 years with a single dose of the Typhoid Conjugate Vaccine (TCV). Approved and pre-qualified by the World Health Organization (WHO), the vaccine provides protection for up to five years and is being administered free under the government’s Expanded Programme on Immunization (EPI).

Published: October 12, 2025.

https://www.reuters.com/business/healthcare-pharmaceuticals/bangladesh-launches-typhoid-vaccination-drive-combat-drug-resistant-threat-2025-10-12/


PAHO releases new guides to help combat vaccine misinformation. 

The Pan American Health Organization (PAHO) launched six new guides designed to support health workers and other professionals in identifying and responding to vaccine misinformation—a growing phenomenon that threatens to undermine confidence in immunization and jeopardize public health progress across the Region.

Published: October 7, 2025.

https://www.paho.org/en/news/7-10-2025-paho-releases-new-guides-help-combat-vaccine-misinformation.


Annual COVID Vaccines Protect People against Severe Disease, Even with Prior Immunity. 

A new study shows that receiving an updated COVID vaccine reduced people’s risk of severe disease and death in all age groups, regardless of immunity from prior infection or vaccination.

Published: October 8, 2025.

https://www.scientificamerican.com/article/new-study-finds-annual-covid-vaccines-protect-people-against-severe-disease/


Japan declares a flu epidemic — what this means for other nations. Researchers say that the number of infections for this time of year is unusual.  

Japan’s health authorities have declared an influenza epidemic, with thousands of people infected with the respiratory virus. The number of infections for this time of year is unusual, say researchers, and could seed outbreaks in countries that are heading into winter in Asia and Europe — although it is unlikely to become a global pandemic.

Published: October 14, 2025.

https://www.nature.com/articles/d41586-025-03367-z

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